Publications

There are numerous publications on the project FOR 2879 in renowned scientific journals. Discover here our collection of publications, covering a range of disciplines, from the theoretical to the applied, highlighting current developments, theories, applications and more.

2021

Marius Piepke, Bettina H Clausen, Peter Ludewig, Jonas H Vienhues, Tanja Bedke, Ehsan Javidi, Björn Rissiek, Larissa Jank, Leonie Brockmann, Inga Sandrock, Karoline Degenhardt, Alina Jander, Vanessa Roth, Ines S Schädlich, Immo Prinz, Richard A Flavell, Yasushi Kobayashi, Thomas Renné, Christian Gerloff, Samuel Huber, Tim Magnus, Mathias Gelderblom. Interleukin-10 improves stroke outcome by controlling the detrimental Interleukin-17A response. J Neuroinflammation. 2021 Nov 13;18(1):265. PMID: 34772416 PMCID: PMC8590298 DOI: 10.1186/s12974-021-02316-7

 

Catharina C Gross, Andreas Schulte-Mecklenbeck, Lohith Madireddy, Marc Pawlitzki, Christine Strippel, Saskia Räuber, Julia Krämer, Leoni Rolfes, Tobias Ruck, Carolin Beuker, Antje Schmidt-Pogoda, Lisa Lohmann, Tilman Schneider-Hohendorf, Tim Hahn, Nicholas Schwab, Jens Minnerup, Nico Melzer, Luisa Klotz, Sven G Meuth, Gerd Meyer Zu Hörste, Sergio E Baranzini, Heinz Wiendl. Classification of neurological diseases using multi-dimensional cerebrospinal fluid analysis. Brain 2021 Oct 22; 144(9):2625-2634 PMID: 33848319 PMCID: PMC8557345 DOI: 10.1093/brain/awab147

Peter Ludewig, Matthias Graeser, Nils D Forkert, Florian Thieben, Javier Rández-Garbayo, Johanna Rieckhoff, Katrin Lessmann, Fynn Förger, Patryk Szwargulski, Tim Magnus, Tobias Knopp. Magnetic particle imaging for assessment of cerebral perfusion and ischemia. Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology, 2021 Oct 6; e1757. PMID: 34617413 DOI: 10.1002/wnan.1757

David Schafflick, Jolien Wolbert, Michael Heming, Christian Thomas, Maike Hartlehnert, Anna-Lena Börsch, Alessio Ricci, Sandra Martín-Salamanca, Xiaolin Li, I-Na Lu, Mathias Pawlak, Jens Minnerup, Jan-Kolja Strecker, Thomas Seidenbecher, Sven G Meuth, Andres Hidalgo, Arthur Liesz, Heinz Wiendl, Gerd Meyer Zu Horste. Single-cell profiling of CNS border compartment leukocytes reveals that B cells and their progenitors reside in non-diseased meninges. Nat Neurosci. 2021 Sep; 24(9):1225-1234. Epub 2021 Jul 12. PMID: 34253922 DOI: 10.1038/s41593-021-00880-y

Dirk M Hermann, Arthur Liesz, Egor Dzyubenko. Implications of immune responses for ischemic brain injury and stroke recovery. Brain Behav Immun. 2021 Aug; 96:292-294. Epub 2021 May 21. PMID: 34023355 DOI: 10.1016/j.bbi.2021.05.020

Iris Lettow, Märit Jensen, Eckhard Schlemm, Florent Boutitie, Fanny Quandt, Bastian Cheng, Martin Ebinger, Matthias Endres, Jochen B Fiebach, Vincent Thijs, Robin Lemmens, Keith W Muir, Norbert Nighoghossian, Salvador Pedraza, Claus Z Simonsen, Christian Gerloff, Götz Thomalla, WAKE-UP Investigators. Serious Adverse Events and Their Impact on Functional Outcome in Acute Ischemic Stroke in the WAKE-UP Trial. Stroke. 2021 Aug 26: STROKEAHA120033425. PMID: 34433305 DOI: 10.1161/STROKEAHA.120.033425

Steffanie Heindl, Alessio Ricci, Olga Carofiglio, Qihui Zhou, Thomas Arzberger, Nikolett Lenart, Nicolai Franzmeier, Tibor Hortobagyi, Peter T Nelson, Ann M Stowe, Adam Denes, Dieter Edbauer, Arthur Liesz. Chronic T cell proliferation in brains after stroke could interfere with the efficacy of immunotherapies. J Exp Med. 2021 Aug 2;218(8):e20202411. Epub 2021 May 26. PMID: 34037669 DOI: 10.1084/jem.20202411

Carolin Beuker, Maximilian Christian Wankner, Christian Thomas, Jan-Kolja Strecker, Antje Schmidt-Pogoda, Wolfram Schwindt, Andreas Schulte-Mecklenbeck, Catharina Gross, Heinz Wiendl, Peter J Barth, Bernd Eckert, Thomas Raphael Meinel, Marcel Arnold, Jens Schaumberg, Schulamith Krüger, Milani Deb-Chatterji, Tim Magnus, Joachim Röther, Jens Minnerup. Characterization of Extracranial Giant Cell Arteritis with Intracranial Involvement and its Rapidly Progressive Subtype. Ann Neurol. 2021 Jul; 90(1): 118-129. Epub 2021 May 28. PMID: 33993547 DOI: 10.1002/ana.26101 

Jonas Gregorius, Chen Wang, Oumaima Stambouli, Tanja Hussner, Yachao Qi, Tobias Tertel, Verena Börger, Ayan Mohamud Yusuf, Nina Hagemann, Dongpei Yin, Robin Dittrich, Yanis Mouloud, Fabian D Mairinger, Fouzi El Magraoui, Aurel Popa-Wagner, Christoph Kleinschnitz, Thorsten R Doeppner, Matthias Gunzer, Helmut E Meyer, Bernd Giebel, Dirk M Hermann. Small extracellular vesicles obtained from hypoxic mesenchymal stromal cells have unique characteristics that promote cerebral angiogenesis, brain remodeling and neurological recovery after focal cerebral ischemia in mice. Basic Res Cardiol 2021 Jun 8; 116(1):40 PMID: 34105014 PMCID: PMC8187185 DOI: 10.1007/s00395-021-00881-9

Gemma Llovera, Alba Simats, Arthur Liesz. Modeling Stroke in Mice: Transient Middle Cerebral Artery Occlusion via the External Carotid Artery. Journal of visualized experiments 2021 May 24; (171): e62573. PMID: 34096920 DOI: 10.3791/62573

Gemma Llovera, Kelsey Pinkham, Arthur Liesz . Modeling Stroke in Mice: Focal Cortical Lesions by Photothrombosis. Journal of visualized experiments 2021 May 24; (171): e62536.​ PMID: 34028443 DOI: 10.3791/62536

Eckhard Schlemm, Thies Ingwersen, Alina Königsberg, Florent Boutitie, Martin Ebinger, Matthias Endres, Jochen B Fiebach, Jens Fiehler, Ivana Galinovic, Robin Lemmens, Keith W Muir, Norbert Nighoghossian, Salvador Pedraza, Josep Puig, Claus Z Simonsen, Vincent Thijs, Anke Wouters, Christian Gerloff, Götz Thomalla, Bastian Cheng. Preserved structural connectivity mediates the clinical effect of thrombolysis in patients with anterior-circulation stroke. 2021 Nature Communications 2021 May 10.  Commun 12, 2590. PMID: 33972513 PMCID: PMC8110812 DOI: 10.1038/s41467-021-22786-w

Ann-Katrin Fleck, Stephanie Hucke, Flavio Teipel, Melanie Eschborn, Claudia Janoschka, Marie Liebmann, Haleluya Wami, Lisanne Korn, Geethanjali Pickert, Marvin Hartwig, Timo Wirth, Martin Herold, Kathrin Koch, Maren Falk-Paulsen, Ulrich Dobrindt, Stjepana Kovac , Catharina C Gross, Philip Rosenstiel, Marcel Trautmann, Heinz Wiendl, Detlef Schuppan , Tanja Kuhlmann, Luisa Klotz. Dietary conjugated linoleic acid links reduced intestinal inflammation to amelioration of CNS autoimmunity. Brain. 2021 May 7; 144(4):1152-1166 PMID: 33899089 PMCID: PMC8105041 DOI: 10.1093/brain/awab040

Jack Winneberger, Sebastian Schöls, Katrin Lessmann, Javier Rández-Garbayo, Alexander T Bauer, Ayan Mohamud Yusuf, Dirk M Hermann, Matthias Gunzer, Stefan W Schneider, Jens Fiehler, Christian Gerloff, Mathias Gelderblom, Peter Ludewig, Tim Magnus. Platelet endothelial cell adhesion molecule-1 is a gatekeeper of neutrophil transendothelial migration in ischemic stroke. Brain, Behavior, and Immunity. 2021 Mar; 93:277-287 PMID: 33388423 DOI: 10.1016/j.bbi.2020.12.026

Vikramjeet Singh, Alexander Beer, Andreas Kraus, Felix Mang, Xiaoni Zhang, Jinhua Xue, Nina Hagemann, Dirk M Hermann, Matthias Gunzer. Stroke increases the expression of ACE2, the SARS-CoV-2 binding receptor, in murine lungs. Brain Behav Immun. 2021 May; 94:458-462. Epub 2021 Feb 20. PMID: 33621620 PMCID: PMC7896496 DOI: 10.1016/j.bbi.2021.01.039

Alessio Vittorio Colombo, Rebecca Katie Sadler, Gemma Llovera, Vikramjeet Singh, Stefan Roth, Steffanie Heindl, Laura Sebastian Monasor, Aswin Verhoeven, Finn Peters, Samira Parhizkar, Frits Kamp, Mercedes Gomez de Aguero, Andrew J MacPherson, Edith Winkler, Jochen Herms, Corinne Benakis, Martin Dichgans, Harald Steiner, Martin Giera, Christian Haass, Sabina Tahirovic, Arthur Liesz. Microbiota-derived short chain fatty acids modulate microglia and promote Aβ plaque deposition. Elife. 2021 Apr 13; 10:e59826. PMID: 33845942 PMCID: PMC8043748 DOI: 10.7554/eLife.59826 

Mengzhe Wang, Tatjana Kleele, Yan Xiao, Gabriela Plucinska, Petros Avramopoulos, Stefan Engelhardt, Markus H Schwab, Matthias Kneussel, Tim Czopka, Diane L Sherman, Peter J Brophy, Thomas Misgeld, Monika S Brill. Completion of neuronal remodeling prompts myelination along developing motor axon branches. Journal of Cell Biology. 2021 Apr 5; 220(4):e201911114. PMID: 33538762 PMCID: PMC7868780 DOI: 10.1083/jcb.201911114 

Stefan Roth, Jiayu Cao, Vikramjeet Singh, Steffen Tiedt, Gabriel Hundeshagen, Ting Li, Julia D Boehme, Dhruv Chauhan, Jie Zhu, Alessio Ricci, Oliver Gorka, Yaw Asare, Jun Yang, Mary S Lopez, Markus Rehberg, Dunja Bruder, Shengxiang Zhang, Olaf Groß, Martin Dichgans, Veit Hornung, Arthur Liesz. Post-injury immunosuppression and secondary infections are caused by an AIM2 inflammasome-driven signaling cascade. Immunity. 2021 Apr 13; 54(4):648-659.e8. Epub 2021 Mar 4. PMID: 33667383 DOI: 10.1016/j.immuni.2021.02.004

Jonas Leinweber, Daniella M Mizurini, Ivo M B Francischetti, Michael Fleischer, Dirk M Hermann, Christoph Kleinschnitz, Friederike Langhauser. Elastase inhibitor agaphelin protects from acute ischemic stroke in mice by reducing thrombosis, blood-brain barrier damage, and inflammation. Brain Behav Immun 2021 Mar;93: 288-298. PMID: 33401017 PMCID: PMC7979502 (available on 2022-03-01) DOI: 10.1016/j.bbi.2020.12.027

Mehrnoosh Jafari, Adrian-Minh Schumacher, Nicolas Snaidero, Emily M Ullrich Gavilanes, Tradite Neziraj, Virág Kocsis-Jutka, Daniel Engels, Tanja Jürgens, Ingrid Wagner, Juan Daniel Flórez Weidinger, Stephanie S Schmidt, Eduardo Beltrán, Nellwyn Hagan, Lisa Woodworth, Dimitry Ofengeim, Joseph Gans, Fred Wolf, Mario Kreutzfeldt, Ruben Portugues, Doron Merkler, Thomas Misgeld, Martin Kerschensteiner. Phagocyte-mediated synapse removal in cortical neuroinflammation is promoted by local calcium accumulation. Nat Neurosci. 2021 Mar; 24(3):355-367. Epub 2021 Jan 25. PMID: 33495636 DOI: 10.1038/s41593-020-00780-7

Jack Winneberger, Sebastian Schöls, Katrin Lessmann, Javier Rández-Garbayo, Alexander T Bauer, Ayan Mohamud Yusuf, Dirk M Hermann, Matthias Gunzer, Stefan W Schneider, Jens Fiehler, Christian Gerloff, Mathias Gelderblom, Peter Ludewig, Tim Magnus. Platelet endothelial cell adhesion molecule-1 is a gatekeeper of neutrophil transendothelial migration in ischemic stroke. Brain Behav Immun. 2021 Mar; 93:277-287. aEpub 2020 Dec 31. PMID: 33388423 DOI: 10.1016/j.bbi.2020.12.026

Kerstin Mülling, Alexa Josephine Fischer, Elena Siakaeva, Mathis Richter, Sharareh Bordbari, Ilona Spyra, Christian Köster, Dirk M Hermann, Matthias Gunzer, Ursula Felderhoff-Müser, Ivo Bendix, Jadwiga Jablonska, Josephine Herz. Neutrophil dynamics, plasticity and function in acute neurodegeneration following neonatal hypoxia-ischemia. Brain Behav Immun. 2021 Feb; 92: 234-244. Epub 2020 Dec 14. PMID: 33333168 DOI: 10.1016/j.bbi.2020.12.012

Stefan Roth, Jun Yang, Julia V Cramer, Rainer Malik, Arthur Liesz. Detection of cytokine-induced sickness behavior after ischemic stroke by an optimized behavioral assessment battery. Brain Behav Immun. 2021 Jan; 91:668-672. Epub 2020 Nov 14. PMID: 33197540 DOI:10.1016/j.bbi.2020.11.016

Carolin Beuker, Jan-Kolja Strecker, Rajesh Rawal, Antje Schmidt-Pogoda, Tobias Ruck, Heinz Wiendl, Luisa Klotz, Wolf-Rüdiger Schäbitz, Clemens J Sommer, Heike Minnerup, Sven G Meuth, Jens Minnerup. Immune Cell Infiltration into the Brain After Ischemic Stroke in Humans Compared to Mice and Rats: a Systematic Review and Meta-Analysis. Transl Stroke Res. 2021 Jan 26. Online ahead of print. PMID: 33496918 DOI: 10.1007/s12975-021-00887-4 

Johannes Boltze, Jaroslaw A Aronowski, Jerome Badaut, Marion S Buckwalter, Mateo Caleo, Michael Chopp, Kunjan R Dave, Nadine Didwischus, Rick M Dijkhuizen, Thorsten R Doeppner, Jens P Dreier, Karim Fouad, Mathias Gelderblom, Karen Gertz, Dominika Golubczyk, Barbara A Gregson, Edith Hamel, Daniel F Hanley, Wolfgang Härtig, Friedhelm C Hummel, Maulana Ikhsan, Miroslaw Janowski, Jukka Jolkkonen, Saravanan S Karuppagounder, Richard F Keep, Inga K Koerte, Zaal Kokaia, Peiying Li, Fudong Liu, Ignacio Lizasoain, Peter Ludewig, Gerlinde A S Metz 40, Axel Montagne, Andre Obenaus, Alex Palumbo, Monica Pearl, Miguel Perez-Pinzon, Anna M Planas, Nikolaus Plesnila, Ami P Raval, Maria A Rueger, Lauren H Sansing, Farida Sohrabji, Charlotte J Stagg, R Anne Stetler, Ann M Stowe, Dandan Sun, Akihiko Taguchi, Mickael Tanter, Sabine U Vay, Raghu Vemuganti, Denis Vivien, Piotr Walczak, Jian Wang, Ye Xiong, Marietta Zille. New Mechanistic Insights, Novel Treatment Paradigms, and Clinical Progress in Cerebrovascular Diseases. Frontiers in aging neuroscience 2021 Jan 28; 13:623751. PMID: 33584250 PMCID: PMC7876251 DOI: 10.3389/fnagi.2021.623751

Dirk M Hermann, Matthias Gunzer. Modulating Microglial Cells for Promoting Brain Recovery and Repair. Front Cell Neurosci. 2021 Jan 11;14:627987. eCollection 2020. PMID: 33505251 PMCID: PMC7829249 DOI: 10.3389/fncel.2020.627987

Anke Baranowsky, Jessika Appelt, Christian Kleber, Tobias Lange, Peter Ludewig, Denise Jahn, Puja Pandey, Daniela Keller, Thomas Rose, Daniela Schetler, Sonja Braumüller, Markus Huber-Lang, Serafeim Tsitsilonis, Timur Yorgan, Karl-Heinz Frosch, Michael Amling, Thorsten Schinke, Johannes Keller. Procalcitonin Exerts a Mediator Role in Septic Shock through the Calcitonin Gene-Related Peptide Receptor. Critical Care Medicine 2021 Jan 1; 49(1):e41-e52 PMID: 33196529 DOI: 10.1097/CCM.0000000000004731

2020

 

Matthias Graeser, Peter Ludewig, Patryk Szwargulski, Fynn Foerger, Tom Liebing, Nils D Forkert, Florian Thieben, Tim Magnus, Tobias Knopp. Design of a head coil for high resolution mouse brain perfusion imaging using magnetic particle imaging. Physics in medicine and biology, 2020 Dec 23; 65(23):235007. PMID: 33049723 DOI: 10.1088/1361-6560/abc09e

Georg Kislinger, Helmut Gnägi, Martin Kerschensteiner, Mikael Simons, Thomas Misgeld, Martina Schifferer. ATUM-FIB microscopy for targeting and multiscale imaging of rare events in mouse cortex. STAR Protoc. 2020 Dec 16; 1(3):100232. eCollection 2020 Dec 18. PMID: 33377119 PMCID: PMC7757728 DOI: 10.1016/j.xpro.2020.100232

Patryk Szwargulski, Maximilian Wilmes, Ehsan Javidi, Florian Thieben, Matthias Graeser, Martin Koch, Cordula Gruettner, Gerhard Adam, Christian Gerloff, Tim Magnus, Tobias Knopp, Peter Ludewig. Monitoring Intracranial Cerebral Hemorrhage Using Multicontrast Real-Time Magnetic Particle Imaging. ACS nano, 2020 Oct 27; 14(10):13913-13923. PMID: 32941000 DOI: 10.1021/acsnano.0c06326

Nina Hagemann , Ayan Mohamud Yusuf, Carlotta Martiny, Xiaoni Zhang, Christoph Kleinschnitz, Matthias Gunzer, Richard Kolesnick, Erich Gulbins, Dirk M Hermann. Homozygous Smpd1 deficiency aggravates brain ischemia/ reperfusion injury by mechanisms involving polymorphonuclear neutrophils, whereas heterozygous Smpd1 deficiency protects against mild focal cerebral ischemia. Basic Res Cardiol 2020 Oct 14; 115(6):64. PMID: 33057972 PMCID: PMC7560939 DOI: 10.1007/s00395-020-00823-x

Nicolas Snaidero, Martina Schifferer, Aleksandra Mezydlo, Bernard Zalc, Martin Kerschensteiner, Thomas Misgeld . Myelin replacement triggered by single-cell demyelination in mouse cortex. Nat Commun. 2020 Sep 29; 11(1):4901. PMID: 32994410 PMCID: PMC7525521 DOI: 10.1038/s41467-020-18632-0

Lisa Ann Gerdes, Claudia Janoschka, Maria Eveslage, Bianca Mannig, Timo Wirth, Andreas Schulte-Mecklenbeck, Sarah Lauks, Laura Glau, Catharina C Gross , Eva Tolosa, Andrea Flierl-Hecht, Birgit Ertl-Wagner, Frederik Barkhof , Sven G Meuth, Tania Kümpfel, Heinz Wiendl, Reinhard Hohlfeld, Luisa Klotz. Immune signatures of prodromal multiple sclerosis in monozygotic twins. Proc Natl Acad Sci U S A 2020 Sep 1; 117(35):21546-21556. PMID: 32817525 PMCID: PMC7474627 DOI: 10.1073/pnas.2003339117

Sina C Rosenkranz, Artem Shaposhnykov, Oliver Schnapauff, Lisa Epping, Vanessa Vieira, Karsten Heidermann, Benjamin Schattling, Volodymyr Tsvilovskyy, Wolfgang Liedtke, Sven G Meuth, Marc Freichel, Mathias Gelderblom, Manuel A Friese. TRPV4-Mediated Regulation of the Blood Brain Barrier Is Abolished During Inflammation. Front Cell Dev Biol. 2020 Aug 27; 8:849. eCollection 2020. PMID: 32974355 PMCID: PMC7481434 DOI: 10.3389/fcell.2020.00849

Katherine D LaClair, Qihui Zhou, Meike Michaelsen, Benedikt Wefers, Monika S Brill, Aleksandar Janjic, Birgit Rathkolb, Daniel Farny, Mikolaj Cygan, Martin Hrabe de Angelis, Wolfgang Wurst, Manuela Neumann, Wolfgang Enard, Thomas Misgeld, Thomas Arzberger, Dieter Edbauer. Congenic expression of poly-GA but not poly-PR in mice triggers selective neuron loss and interferon responses found in C9orf72 ALS. Acta Neuropathol. 2020 Aug; 140(2):121-142. Epub 2020 Jun 19. PMID: 32562018 PMCID: PMC7360660 DOI: 10.1007/s00401-020-02176-0 Free PMC article

Santra Brenna, Hermann C Altmeppen, Behnam Mohammadi, Björn Rissiek, Florence Schlink, Peter Ludewig, Christoph Krisp, Hartmut Schlüter, Antonio Virgilio Failla, Carola Schneider, Markus Glatzel, Berta Puig, Tim Magnus. Characterization of brain-derived extracellular vesicles reveals changes in cellular origin after stroke and enrichment of the prion protein with a potential role in cellular uptake. Journal of Extracellular Vesicles 2020 Aug 27; 9(1):1809065 PMID: 32944194 PMCID: PMC7480459 DOI: 10.1080/20013078.2020.1809065

Georg Kislinger, Helmut Gnägi, Martin Kerschensteiner, Mikael Simons, Thomas Misgeld, Martina Schifferer. Multiscale ATUM-FIB Microscopy Enables Targeted Ultrastructural Analysis at Isotropic Resolution. iScience. 2020 Jul 24; 23(7):101290. Epub 2020 Jun 20. PMID: 32622266 PMCID: PMC7334410 DOI: 10.1016/j.isci.2020.101290

Chen Wang, Verena Börger, Maryam Sardari, Florian Murke, Jelena Skuljec, Refik Pul, Nina Hagemann, Egor Dzyubenko, Robin Dittrich, Jonas Gregorius, Mike Hasenberg, Christoph Kleinschnitz, Aurel Popa-Wagner, Thorsten R Doeppner, Matthias Gunzer, Bernd Giebel, Dirk M Hermann. Mesenchymal Stromal Cell-Derived Small Extracellular Vesicles Induce Ischemic Neuroprotection by Modulating Leukocytes and Specifically Neutrophils. Stroke. 2020 Jun; 51(6):1825-1834. Epub 2020 Apr 21. PMID: 32312217 DOI: 10.1161/STROKEAHA.119.028012

Jan Wenzel, Cathrin E Hansen, Carla Bettoni, Miriam A Vogt, Beate Lembrich, Rentsenkhand Natsagdorj, Gianna Huber, Josefine Brands, Kjestine Schmidt, Julian C Assmann, Ines Stölting, Kathrin Saar, Jan Sedlacik, Jens Fiehler, Peter Ludewig, Michael Wegmann, Nina Feller, Marius Richter, Helge Müller-Fielitz, Thomas Walther, Gabriele M König, Evi Kostenis, Walter Raasch, Norbert Hübner, Peter Gass, Stefan Offermanns, Cor de Wit, Carsten A Wagner, Markus Schwaninger. Impaired endothelium-mediated cerebrovascular reactivity promotes anxiety and respiration disorders in mice. Proceedings of the National Academy of Sciences of the United States of America, 117(3). 2020 Jan 21; 117(3):1753-1761. PMID: 31896584 PMCID: PMC6983400 DOI: 10.1073/pnas.1907467117

Csaba Cserép, Balázs Pósfai, Nikolett Lénárt, Rebeka Fekete, Zsófia I László, Zsolt Lele, Barbara Orsolits, Gábor Molnár, Steffanie Heindl, Anett D Schwarcz, Katinka Ujvári, Zsuzsanna Környei, Krisztina Tóth, Eszter Szabadits, Beáta Sperlágh, Mária Baranyi, László Csiba, Tibor Hortobágyi, Zsófia Maglóczky, Bernadett Martinecz, Gábor Szabó, Ferenc Erdélyi, Róbert Szipőcs, Michael M Tamkun, Benno Gesierich, Marco Duering, István Katona, Arthur Liesz, Gábor Tamás, Ádám Dénes. Microglia monitor and protect neuronal function through specialized somatic purinergic junctions. Science. 2020 Jan 31; 367(6477):528-537. Epub 2019 Dec 12. PMID: 31831638 DOI: 10.1126/science.aax6752

Antje Schmidt-Pogoda, Nadine Bonberg, Mailin Hannah Marie Koecke, Jan-Kolja Strecker, Jürgen W ellmann, Nils-Martin Bruckmann, Carolin Beuker, Wolf-Rüdiger Schäbitz, Sven G Meuth, Heinz Wiendl, Heike Minnerup, Jens Minnerup.  Why Most Acute Stroke Studies Are Positive in Animals but Not in Patients: A Systematic Comparison of Preclinical, Early Phase, and Phase 3 Clinical Trials of Neuroprotective Agents. Ann Neurol. 2020 Jan; 87(1):40-51. Epub 2019 Nov 26. PMID: 31714631 DOI: 10.1002/ana.25643

Eckhard Schlemm, Robert Schulz, Marlene Bönstrup, Lutz Krawinkel, Jens Fiehler, Christian Gerloff, Götz Thomalla, Bastian Cheng. Structural brain networks and functional motor outcome after stroke-a prospective cohort study. Brain Commun 2020 Jan 10; 2(1): fcaa001. eCollection 2020. PMID: 32954275 PMCID: PMC7425342 DOI: 10.1093/braincomms/fcaa001

2019

Catharina C Gross, Céline Meyer, Urvashi Bhatia, Lidia Yshii, Ilka Kleffner, Jan Bauer, Anna R Tröscher, Andreas Schulte-Mecklenbeck, Sebastian Herich, Tilman Schneider-Hohendorf, Henrike Plate, Tanja Kuhlmann, Markus Schwaninger, Wolfgang Brück, Marc Pawlitzki, David-Axel Laplaud, Delphine Loussouarn, John Parratt, Michael Barnett, Michael E Buckland, Todd A Hardy, Stephen W Reddel, Marius Ringelstein, Jan Dörr, Brigitte Wildemann, Markus Kraemer, Hans Lassmann, Romana Höftberger, Eduardo Beltrán, Klaus Dornmair, Nicholas Schwab, Luisa Klotz, Sven G Meuth, Guillaume Martin-Blondel, Heinz Wiendl, Roland Liblau. CD8+ T cell-mediated endotheliopathy is a targetable mechanism of neuro-inflammation in Susac syndrome. Nat Commun 2019 Dec 18; 10(1):5779. PMID: 31852955 PMCID: PMC6920411 DOI: 10.1038/s41467-019-13593-5

Dirk M Hermann, Matthias Gunzer. Contribution of polymorphonuclear neutrophils in the blood periphery to ischemic brain injury. Neurol Neuroimmunol Neuroinflamm. 2019 May 15; 6(4):e570. doi: 10.1212/NXI.0000000000000570. eCollection 2019 Jul. PMID: 31355306 PMCID: PMC6624096 DOI: 10.1212/NXI.0000000000000570

Simon F Merz, Sebastian Korste, Lea Bornemann, Lars Michel, Pia Stock, Anthony Squire, Camille Soun, Daniel R Engel, Julia Detzer, Holger Lörchner, Dirk M Hermann, Markus Kamler, Joachim Klode, Ulrike B Hendgen-Cotta, Tienush Rassaf, Matthias Gunzer, Matthias Totzeck. Contemporaneous 3D characterization of acute and chronic myocardial I/R injury and response. Nat Commun. 2019 Jun 19;10(1): 2768.. PMID: 31217436 PMCID: PMC6584493 DOI: 10.1038/s41467-019-10804-x

Luisa Klotz, Melanie Eschborn, Maren Lindner, Marie Liebmann, Martin Herold, Claudia Janoschka, Belén Torres Garrido, Andreas Schulte-Mecklenbeck, Catharina C Gross, Johanna Breuer, Petra Hundehege, Vilmos Posevitz, Béatrice Pignolet, Giulia Nebel, Shirin Glander, Nicole Freise, Judith Austermann, Timo Wirth, Graham R Campbell, Tilman Schneider-Hohendorf, Maria Eveslage, David Brassat, Nicholas Schwab, Karin Loser, Johannes Roth, Karin B Busch, Monika Stoll, Don J Mahad, Sven G Meuth, Timothy Turner, Amit Bar-Or, Heinz Wiendl. Teriflunomide treatment for multiple sclerosis modulates T cell mitochondrial respiration with affinity-dependent effects. Sci Transl Med 2019 May 1; 11(490):eaao5563. PMID: 31043571 DOI: 10.1126/scitranslmed.aao5563

Dirk M Hermann, Matthias Gunzer. Polymorphonuclear Neutrophils Play a Decisive Role for Brain Injury and Neurological Recovery Poststroke. Stroke. 2019 Mar; 50(3):e40-e41. PMID: 30674233 DOI: 10.1161/STROKEAHA.118.021564

2018 and 2017

Dirk M Hermann, Christoph Kleinschnitz, Matthias Gunzer. Role of polymorphonuclear neutrophils in the reperfused ischemic brain: insights from cell-type-specific immunodepletion and fluorescence microscopy studies. Ther Adv Neurol Disord. 2018 Sep 14; 11:1756286418798607. eCollection 2018. PMID: 30245743 PMCID: PMC6144496 DOI: 10.1177/1756286418798607

Dirk M Hermann, Christoph Kleinschnitz, Matthias Gunzer. Implications of polymorphonuclear neutrophils for ischemic stroke and intracerebral hemorrhage: Predictive value, pathophysiological consequences and utility as therapeutic target.  J Neuroimmunol. 2018 Aug 15; 321:138-143. Epub 2018 Apr 24. PMID: 29729895 DOI: 10.1016/j.jneuroim.2018.04.015

Bastian Cheng, Christian Knaack, Nils Daniel Forkert, Renate Schnabel, Christian Gerloff, Götz Thomalla. Stroke subtype classification by geometrical descriptors of lesion shape. PLoS One 2017 Dec 7; 12(12):e0185063. eCollection 2017 PMID: 29216218 PMCID: PMC5720627 DOI: 10.1371/journal.pone.018506