Corinne Benakis, Alba Simats, Sophie Tritschler, Steffanie Heindl, Simon Besson-Girard, Gemma Llovera, Kelsey Pinkham, Anna Kolz, Alessio Ricci, Fabian J Theis, Stefan Bittner, Özgün Gökce, Anneli Peters, Arthur Liesz. T cells modulate the microglial response to brain ischemia. Elife. 2022 Dec 13;11:e82031. PMID: 36512388 PMCID: PMC9747154 DOI: 10.7554/eLife.82031

Maximilian Wilmes, Carolina Pinto Espinoza, Peter Ludewig, Joschi Stabernack, Arthur Liesz, Annette Nicke, Mathias Gelderblom, Christian Gerloff, Simonetta Falzoni, Eva Tolosa, Francesco Di Virgilio, Björn Rissiek, Nikolaus Plesnilla, Friedrich Koch-Nolte, Tim Magnus. Blocking P2X7 by intracerebroventricular injection of P2X7-specific nanobodies reduces stroke lesions. J Neuroinflammation. 2022 Oct 12;19(1):256. PMID: 36224611 PMCID: PMC9559872 DOI: 10.1186/s12974-022-02601-z

Artem Zatcepin, Steffanie Heindl, Ulrike Schillinger, Lena Kaiser, Simon Lindner, Peter Bartenstein, Anna Kopczak, Arthur Liesz, Matthias Brendel, Sibylle I. Ziegler. Reduced Acquisition Time [¹⁸F]GE-180 PET Scanning Protocol Replaces Gold-Standard Dynamic Acquisition in a Mouse Ischemic Stroke Model. Front Med (Lausanne). 2022 Feb 10;9:830020. PMID: 35223925 PMCID: PMC8866959 DOI: 10.3389/fmed.2022.830020

Lucia Beckmann, Stefanie Obst, Nicole Labusek, Hanna Abberger, Christian Köster, Ludger Klein-Hitpass, Sven Schumann, Christoph Kleinschnitz, Dirk M Hermann, Ursula Felderhoff-Müser, Ivo Bendix, Wiebke Hansen, Josephine Herz. Regulatory T cells contribute to sexual dimorphism in neonatal hypoxic-ischemic brain injury. Stroke. 2022 Feb; 53(2):381-390. PMID: 34983246 PMCID: PMC8785522 DOI: 10.1161/STROKEAHA.121.037537

Leoni Rolfes, Tobias Ruck, Christina David, Stine Mencl, Stefanie Bock, Mariella Schmidt, Jan-Kolja Strecker, Steffen Pfeuffer, Andreas-Schulte Mecklenbeck, Catharina Gross, Michael Gliem, Jens Minnerup, Michael K Schuhmann, Christoph Kleinschnitz, Sven G Meuth. Natural Killer Cells Are Present in Rag1 (-/-) Mice and Promote Tissue Damage During the Acute Phase of Ischemic Stroke. Transl Stroke Res. 2022 Feb; 13(1):197-211. PMID: 34105078 PMCID: PMC8766401 DOI: 10.1007/s12975-021-00923-3

Chen Wang, Verena Börger, Ayan Mohamud Yusuf, Tobias Tertel, Oumaima Stambouli, Florian Murke, Nico Freund, Christoph Kleinschnitz, Josephine Herz, Matthias Gunzer, Aurel Popa-Wagner, Thorsten R Doeppner, Bernd Giebel, Dirk M Hermann. Postischemic Neuroprotection Associated With Anti-Inflammatory Effects by Mesenchymal Stromal Cell-Derived Small Extracellular Vesicles in Aged Mice. Stroke. 2022 Jan; 53(1):e14-e18. PMID: 34847707 PMCID: PMC8700303 DOI: 10.1161/STROKEAHA.121.035821

Mustafa C Beker, Ahmet B Caglayan, Serdar Altunay, Elif Ozbay, Nilay Ates, Taha Kelestemur, Berrak Caglayan, Ulkan Kilic, Thorsten R Doeppner, Dirk M Hermann, Ertugrul Kilic. Phosphodiesterase 10A Is a Critical Target for Neuroprotection in a Mouse Model of Ischemic StrokeMol Neurobiol. Mol Neurobiol. 2022 Jan; 59(1):574-589. PMID: 34735672 DOI: 10.1007/s12035-021-02621-5

Sina C Rosenkranz, Vivien Häußler, Manuela Kolster, Anne Willing, Jakob Matschke, Christoph Röcken, Klarissa Stürner, Frank Leypoldt, Eva Tolosa, Manuel A Friese. Treating sarcoidosis-associated progressive multifocal leukoencephalopathy with infliximab. Brain Commun 2021 Dec 16; 4(1): fcab292. PMID: 34993476 PMCID: PMC8727989 DOI: 10.1093/braincomms/fcab292

Marius Piepke, Bettina H Clausen, Peter Ludewig, Jonas H Vienhues, Tanja Bedke, Ehsan Javidi, Björn Rissiek, Larissa Jank, Leonie Brockmann, Inga Sandrock, Karoline Degenhardt, Alina Jander, Vanessa Roth, Ines S Schädlich, Immo Prinz, Richard A Flavell, Yasushi Kobayashi, Thomas Renné, Christian Gerloff, Samuel Huber, Tim Magnus, Mathias Gelderblom. Interleukin-10 improves stroke outcome by controlling the detrimental Interleukin-17A response. J Neuroinflammation. 2021 Nov 13;18(1):265. PMID: 34772416 PMCID: PMC8590298 DOI: 10.1186/s12974-021-02316-7

Catharina C Gross, Andreas Schulte-Mecklenbeck, Lohith Madireddy, Marc Pawlitzki, Christine Strippel, Saskia Räuber, Julia Krämer, Leoni Rolfes, Tobias Ruck, Carolin Beuker, Antje Schmidt-Pogoda, Lisa Lohmann, Tilman Schneider-Hohendorf, Tim Hahn, Nicholas Schwab, Jens Minnerup, Nico Melzer, Luisa Klotz, Sven G Meuth, Gerd Meyer Zu Hörste, Sergio E Baranzini, Heinz Wiendl. Classification of neurological diseases using multi-dimensional cerebrospinal fluid analysis. Brain 2021 Oct 22; 144(9):2625-2634 PMID: 33848319 PMCID: PMC8557345 DOI: 10.1093/brain/awab147

Enja Schneider, Riekje Winzer, Anne Rissiek, Isabell Ricklefs, Catherine Meyer-Schwesinger, Franz L Ricklefs, Andreas Bauche, Jochen Behrends, Rudolph Reimer, Santra Brenna, Hauke Wasielewski, Melchior Lauten, Björn Rissiek, Berta Puig, Filippo Cortesi, Tim Magnus, Ralf Fliegert, Christa E Müller, Nicola Gagliani, Eva Tolosa. CD73-mediated adenosine production by CD8 T cell-derived extracellular vesicles constitutes an intrinsic mechanism of immune suppression. Nat Commun 2021 Oct 8;12(1):5911. PMID: 34625545 PMCID: PMC8501027 DOI: 10.1038/s41467-021-26134-w

Peter Ludewig, Matthias Graeser, Nils D Forkert, Florian Thieben, Javier Rández-Garbayo, Johanna Rieckhoff, Katrin Lessmann, Fynn Förger, Patryk Szwargulski, Tim Magnus, Tobias Knopp. Magnetic particle imaging for assessment of cerebral perfusion and ischemia. Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology, 2021 Oct 6; e1757. PMID: 34617413 DOI: 10.1002/wnan.1757

David Schafflick, Jolien Wolbert, Michael Heming, Christian Thomas, Maike Hartlehnert, Anna-Lena Börsch, Alessio Ricci, Sandra Martín-Salamanca, Xiaolin Li, I-Na Lu, Mathias Pawlak, Jens Minnerup, Jan-Kolja Strecker, Thomas Seidenbecher, Sven G Meuth, Andres Hidalgo, Arthur Liesz, Heinz Wiendl, Gerd Meyer Zu Horste. Single-cell profiling of CNS border compartment leukocytes reveals that B cells and their progenitors reside in non-diseased meninges. Nat Neurosci. 2021 Sep; 24(9):1225-1234. Epub 2021 Jul 12. PMID: 34253922 DOI: 10.1038/s41593-021-00880-y

Dirk M Hermann, Arthur Liesz, Egor Dzyubenko. Implications of immune responses for ischemic brain injury and stroke recovery. Brain Behav Immun. 2021 Aug; 96:292-294. Epub 2021 May 21. PMID: 34023355 DOI: 10.1016/j.bbi.2021.05.020

Iris Lettow, Märit Jensen, Eckhard Schlemm, Florent Boutitie, Fanny Quandt, Bastian Cheng, Martin Ebinger, Matthias Endres, Jochen B Fiebach, Vincent Thijs, Robin Lemmens, Keith W Muir, Norbert Nighoghossian, Salvador Pedraza, Claus Z Simonsen, Christian Gerloff, Götz Thomalla, WAKE-UP Investigators. Serious Adverse Events and Their Impact on Functional Outcome in Acute Ischemic Stroke in the WAKE-UP Trial. Stroke. 2021 Aug 26: STROKEAHA120033425. PMID: 34433305 DOI: 10.1161/STROKEAHA.120.033425

Steffanie Heindl, Alessio Ricci, Olga Carofiglio, Qihui Zhou, Thomas Arzberger, Nikolett Lenart, Nicolai Franzmeier, Tibor Hortobagyi, Peter T Nelson, Ann M Stowe, Adam Denes, Dieter Edbauer, Arthur Liesz. Chronic T cell proliferation in brains after stroke could interfere with the efficacy of immunotherapies. J Exp Med. 2021 Aug 2;218(8):e20202411. Epub 2021 May 26. PMID: 34037669 DOI: 10.1084/jem.20202411

Carolin Beuker, Maximilian Christian Wankner, Christian Thomas, Jan-Kolja Strecker, Antje Schmidt-Pogoda, Wolfram Schwindt, Andreas Schulte-Mecklenbeck, Catharina Gross, Heinz Wiendl, Peter J Barth, Bernd Eckert, Thomas Raphael Meinel, Marcel Arnold, Jens Schaumberg, Schulamith Krüger, Milani Deb-Chatterji, Tim Magnus, Joachim Röther, Jens Minnerup. Characterization of Extracranial Giant Cell Arteritis with Intracranial Involvement and its Rapidly Progressive Subtype. Ann Neurol. 2021 Jul; 90(1): 118-129. Epub 2021 May 28. PMID: 33993547 DOI: 10.1002/ana.26101 

Jonas Gregorius, Chen Wang, Oumaima Stambouli, Tanja Hussner, Yachao Qi, Tobias Tertel, Verena Börger, Ayan Mohamud Yusuf, Nina Hagemann, Dongpei Yin, Robin Dittrich, Yanis Mouloud, Fabian D Mairinger, Fouzi El Magraoui, Aurel Popa-Wagner, Christoph Kleinschnitz, Thorsten R Doeppner, Matthias Gunzer, Helmut E Meyer, Bernd Giebel, Dirk M Hermann. Small extracellular vesicles obtained from hypoxic mesenchymal stromal cells have unique characteristics that promote cerebral angiogenesis, brain remodeling and neurological recovery after focal cerebral ischemia in mice. Basic Res Cardiol 2021 Jun 8; 116(1):40 PMID: 34105014 PMCID: PMC8187185 DOI: 10.1007/s00395-021-00881-9

Gemma Llovera, Alba Simats, Arthur Liesz. Modeling Stroke in Mice: Transient Middle Cerebral Artery Occlusion via the External Carotid Artery. Journal of visualized experiments 2021 May 24; (171): e62573. PMID: 34096920 DOI: 10.3791/62573

Gemma Llovera, Kelsey Pinkham, Arthur Liesz . Modeling Stroke in Mice: Focal Cortical Lesions by Photothrombosis. Journal of visualized experiments 2021 May 24; (171): e62536.​ PMID: 34028443 DOI: 10.3791/62536

Eckhard Schlemm, Thies Ingwersen, Alina Königsberg, Florent Boutitie, Martin Ebinger, Matthias Endres, Jochen B Fiebach, Jens Fiehler, Ivana Galinovic, Robin Lemmens, Keith W Muir, Norbert Nighoghossian, Salvador Pedraza, Josep Puig, Claus Z Simonsen, Vincent Thijs, Anke Wouters, Christian Gerloff, Götz Thomalla, Bastian Cheng. Preserved structural connectivity mediates the clinical effect of thrombolysis in patients with anterior-circulation stroke. 2021 Nature Communications 2021 May 10.  Commun 12, 2590. PMID: 33972513 PMCID: PMC8110812 DOI: 10.1038/s41467-021-22786-w

Ann-Katrin Fleck, Stephanie Hucke, Flavio Teipel, Melanie Eschborn, Claudia Janoschka, Marie Liebmann, Haleluya Wami, Lisanne Korn, Geethanjali Pickert, Marvin Hartwig, Timo Wirth, Martin Herold, Kathrin Koch, Maren Falk-Paulsen, Ulrich Dobrindt, Stjepana Kovac , Catharina C Gross, Philip Rosenstiel, Marcel Trautmann, Heinz Wiendl, Detlef Schuppan , Tanja Kuhlmann, Luisa Klotz. Dietary conjugated linoleic acid links reduced intestinal inflammation to amelioration of CNS autoimmunity. Brain. 2021 May 7; 144(4):1152-1166 PMID: 33899089 PMCID: PMC8105041 DOI: 10.1093/brain/awab040

Jack Winneberger, Sebastian Schöls, Katrin Lessmann, Javier Rández-Garbayo, Alexander T Bauer, Ayan Mohamud Yusuf, Dirk M Hermann, Matthias Gunzer, Stefan W Schneider, Jens Fiehler, Christian Gerloff, Mathias Gelderblom, Peter Ludewig, Tim Magnus. Platelet endothelial cell adhesion molecule-1 is a gatekeeper of neutrophil transendothelial migration in ischemic stroke. Brain, Behavior, and Immunity. 2021 Mar; 93:277-287 PMID: 33388423 DOI: 10.1016/j.bbi.2020.12.026

Vikramjeet Singh, Alexander Beer, Andreas Kraus, Felix Mang, Xiaoni Zhang, Jinhua Xue, Nina Hagemann, Dirk M Hermann, Matthias Gunzer. Stroke increases the expression of ACE2, the SARS-CoV-2 binding receptor, in murine lungs. Brain Behav Immun. 2021 May; 94:458-462. Epub 2021 Feb 20. PMID: 33621620 PMCID: PMC7896496 DOI: 10.1016/j.bbi.2021.01.039

Alessio Vittorio Colombo, Rebecca Katie Sadler, Gemma Llovera, Vikramjeet Singh, Stefan Roth, Steffanie Heindl, Laura Sebastian Monasor, Aswin Verhoeven, Finn Peters, Samira Parhizkar, Frits Kamp, Mercedes Gomez de Aguero, Andrew J MacPherson, Edith Winkler, Jochen Herms, Corinne Benakis, Martin Dichgans, Harald Steiner, Martin Giera, Christian Haass, Sabina Tahirovic, Arthur Liesz. Microbiota-derived short chain fatty acids modulate microglia and promote Aβ plaque deposition. Elife. 2021 Apr 13; 10:e59826. PMID: 33845942 PMCID: PMC8043748 DOI: 10.7554/eLife.59826 

Mengzhe Wang, Tatjana Kleele, Yan Xiao, Gabriela Plucinska, Petros Avramopoulos, Stefan Engelhardt, Markus H Schwab, Matthias Kneussel, Tim Czopka, Diane L Sherman, Peter J Brophy, Thomas Misgeld, Monika S Brill. Completion of neuronal remodeling prompts myelination along developing motor axon branches. Journal of Cell Biology. 2021 Apr 5; 220(4):e201911114. PMID: 33538762 PMCID: PMC7868780 DOI: 10.1083/jcb.201911114 

Stefan Roth, Jiayu Cao, Vikramjeet Singh, Steffen Tiedt, Gabriel Hundeshagen, Ting Li, Julia D Boehme, Dhruv Chauhan, Jie Zhu, Alessio Ricci, Oliver Gorka, Yaw Asare, Jun Yang, Mary S Lopez, Markus Rehberg, Dunja Bruder, Shengxiang Zhang, Olaf Groß, Martin Dichgans, Veit Hornung, Arthur Liesz. Post-injury immunosuppression and secondary infections are caused by an AIM2 inflammasome-driven signaling cascade. Immunity. 2021 Apr 13; 54(4):648-659.e8. Epub 2021 Mar 4. PMID: 33667383 DOI: 10.1016/j.immuni.2021.02.004

Jonas Leinweber, Daniella M Mizurini, Ivo M B Francischetti, Michael Fleischer, Dirk M Hermann, Christoph Kleinschnitz, Friederike Langhauser. Elastase inhibitor agaphelin protects from acute ischemic stroke in mice by reducing thrombosis, blood-brain barrier damage, and inflammation. Brain Behav Immun 2021 Mar;93: 288-298. PMID: 33401017 PMCID: PMC7979502 (available on 2022-03-01) DOI: 10.1016/j.bbi.2020.12.027

Mehrnoosh Jafari, Adrian-Minh Schumacher, Nicolas Snaidero, Emily M Ullrich Gavilanes, Tradite Neziraj, Virág Kocsis-Jutka, Daniel Engels, Tanja Jürgens, Ingrid Wagner, Juan Daniel Flórez Weidinger, Stephanie S Schmidt, Eduardo Beltrán, Nellwyn Hagan, Lisa Woodworth, Dimitry Ofengeim, Joseph Gans, Fred Wolf, Mario Kreutzfeldt, Ruben Portugues, Doron Merkler, Thomas Misgeld, Martin Kerschensteiner. Phagocyte-mediated synapse removal in cortical neuroinflammation is promoted by local calcium accumulation. Nat Neurosci. 2021 Mar; 24(3):355-367. Epub 2021 Jan 25. PMID: 33495636 DOI: 10.1038/s41593-020-00780-7

Jack Winneberger, Sebastian Schöls, Katrin Lessmann, Javier Rández-Garbayo, Alexander T Bauer, Ayan Mohamud Yusuf, Dirk M Hermann, Matthias Gunzer, Stefan W Schneider, Jens Fiehler, Christian Gerloff, Mathias Gelderblom, Peter Ludewig, Tim Magnus. Platelet endothelial cell adhesion molecule-1 is a gatekeeper of neutrophil transendothelial migration in ischemic stroke. Brain Behav Immun. 2021 Mar; 93:277-287. aEpub 2020 Dec 31. PMID: 33388423 DOI: 10.1016/j.bbi.2020.12.026

Kerstin Mülling, Alexa Josephine Fischer, Elena Siakaeva, Mathis Richter, Sharareh Bordbari, Ilona Spyra, Christian Köster, Dirk M Hermann, Matthias Gunzer, Ursula Felderhoff-Müser, Ivo Bendix, Jadwiga Jablonska, Josephine Herz. Neutrophil dynamics, plasticity and function in acute neurodegeneration following neonatal hypoxia-ischemia. Brain Behav Immun. 2021 Feb; 92: 234-244. Epub 2020 Dec 14. PMID: 33333168 DOI: 10.1016/j.bbi.2020.12.012

Stefan Roth, Jun Yang, Julia V Cramer, Rainer Malik, Arthur Liesz. Detection of cytokine-induced sickness behavior after ischemic stroke by an optimized behavioral assessment battery. Brain Behav Immun. 2021 Jan; 91:668-672. Epub 2020 Nov 14. PMID: 33197540 DOI:10.1016/j.bbi.2020.11.016

Carolin Beuker, Jan-Kolja Strecker, Rajesh Rawal, Antje Schmidt-Pogoda, Tobias Ruck, Heinz Wiendl, Luisa Klotz, Wolf-Rüdiger Schäbitz, Clemens J Sommer, Heike Minnerup, Sven G Meuth, Jens Minnerup. Immune Cell Infiltration into the Brain After Ischemic Stroke in Humans Compared to Mice and Rats: a Systematic Review and Meta-Analysis. Transl Stroke Res. 2021 Jan 26. Online ahead of print. PMID: 33496918 DOI: 10.1007/s12975-021-00887-4 

Johannes Boltze, Jaroslaw A Aronowski, Jerome Badaut, Marion S Buckwalter, Mateo Caleo, Michael Chopp, Kunjan R Dave, Nadine Didwischus, Rick M Dijkhuizen, Thorsten R Doeppner, Jens P Dreier, Karim Fouad, Mathias Gelderblom, Karen Gertz, Dominika Golubczyk, Barbara A Gregson, Edith Hamel, Daniel F Hanley, Wolfgang Härtig, Friedhelm C Hummel, Maulana Ikhsan, Miroslaw Janowski, Jukka Jolkkonen, Saravanan S Karuppagounder, Richard F Keep, Inga K Koerte, Zaal Kokaia, Peiying Li, Fudong Liu, Ignacio Lizasoain, Peter Ludewig, Gerlinde A S Metz 40, Axel Montagne, Andre Obenaus, Alex Palumbo, Monica Pearl, Miguel Perez-Pinzon, Anna M Planas, Nikolaus Plesnila, Ami P Raval, Maria A Rueger, Lauren H Sansing, Farida Sohrabji, Charlotte J Stagg, R Anne Stetler, Ann M Stowe, Dandan Sun, Akihiko Taguchi, Mickael Tanter, Sabine U Vay, Raghu Vemuganti, Denis Vivien, Piotr Walczak, Jian Wang, Ye Xiong, Marietta Zille. New Mechanistic Insights, Novel Treatment Paradigms, and Clinical Progress in Cerebrovascular Diseases. Frontiers in aging neuroscience 2021 Jan 28; 13:623751. PMID: 33584250 PMCID: PMC7876251 DOI: 10.3389/fnagi.2021.623751

Dirk M Hermann, Matthias Gunzer. Modulating Microglial Cells for Promoting Brain Recovery and Repair. Front Cell Neurosci. 2021 Jan 11;14:627987. eCollection 2020. PMID: 33505251 PMCID: PMC7829249 DOI: 10.3389/fncel.2020.627987

Anke Baranowsky, Jessika Appelt, Christian Kleber, Tobias Lange, Peter Ludewig, Denise Jahn, Puja Pandey, Daniela Keller, Thomas Rose, Daniela Schetler, Sonja Braumüller, Markus Huber-Lang, Serafeim Tsitsilonis, Timur Yorgan, Karl-Heinz Frosch, Michael Amling, Thorsten Schinke, Johannes Keller. Procalcitonin Exerts a Mediator Role in Septic Shock through the Calcitonin Gene-Related Peptide Receptor. Critical Care Medicine 2021 Jan 1; 49(1):e41-e52 PMID: 33196529 DOI: 10.1097/CCM.0000000000004731

 Matthias Graeser, Peter Ludewig, Patryk Szwargulski, Fynn Foerger, Tom Liebing, Nils D Forkert, Florian Thieben, Tim Magnus, Tobias Knopp. Design of a head coil for high resolution mouse brain perfusion imaging using magnetic particle imaging. Physics in medicine and biology, 2020 Dec 23; 65(23):235007. PMID: 33049723 DOI: 10.1088/1361-6560/abc09e

Malte Mohme, Thomas Sauvigny, Marius Marc-Daniel Mader, Nils Schweingruber, Cecile L Maire, Alessandra Rünger, Franz Ricklefs, Jan Regelsberger, Nils Ole Schmidt, Manfred Westphal, Katrin Lamszus, Eva Tolosa, Patrick Czorlich. Immune Characterization in Aneurysmal Subarachnoid Hemorrhage Reveals Distinct Monocytic Activation and Chemokine Patterns. Transl Stroke Res 2020 Dec;11(6):1348-1361. PMID: 31858408 DOI: 10.1007/s12975-019-00764-1

Georg Kislinger, Helmut Gnägi, Martin Kerschensteiner, Mikael Simons, Thomas Misgeld, Martina Schifferer. ATUM-FIB microscopy for targeting and multiscale imaging of rare events in mouse cortex. STAR Protoc. 2020 Dec 16; 1(3):100232. eCollection 2020 Dec 18. PMID: 33377119 PMCID: PMC7757728 DOI: 10.1016/j.xpro.2020.100232

Patryk Szwargulski, Maximilian Wilmes, Ehsan Javidi, Florian Thieben, Matthias Graeser, Martin Koch, Cordula Gruettner, Gerhard Adam, Christian Gerloff, Tim Magnus, Tobias Knopp, Peter Ludewig. Monitoring Intracranial Cerebral Hemorrhage Using Multicontrast Real-Time Magnetic Particle Imaging. ACS nano, 2020 Oct 27; 14(10):13913-13923. PMID: 32941000 DOI: 10.1021/acsnano.0c06326

Nina Hagemann , Ayan Mohamud Yusuf, Carlotta Martiny, Xiaoni Zhang, Christoph Kleinschnitz, Matthias Gunzer, Richard Kolesnick, Erich Gulbins, Dirk M Hermann. Homozygous Smpd1 deficiency aggravates brain ischemia/ reperfusion injury by mechanisms involving polymorphonuclear neutrophils, whereas heterozygous Smpd1 deficiency protects against mild focal cerebral ischemia. Basic Res Cardiol 2020 Oct 14; 115(6):64. PMID: 33057972 PMCID: PMC7560939 DOI: 10.1007/s00395-020-00823-x

Nicolas Snaidero, Martina Schifferer, Aleksandra Mezydlo, Bernard Zalc, Martin Kerschensteiner, Thomas Misgeld . Myelin replacement triggered by single-cell demyelination in mouse cortex. Nat Commun. 2020 Sep 29; 11(1):4901. PMID: 32994410 PMCID: PMC7525521 DOI: 10.1038/s41467-020-18632-0

Lisa Ann Gerdes, Claudia Janoschka, Maria Eveslage, Bianca Mannig, Timo Wirth, Andreas Schulte-Mecklenbeck, Sarah Lauks, Laura Glau, Catharina C Gross , Eva Tolosa, Andrea Flierl-Hecht, Birgit Ertl-Wagner, Frederik Barkhof , Sven G Meuth, Tania Kümpfel, Heinz Wiendl, Reinhard Hohlfeld, Luisa Klotz. Immune signatures of prodromal multiple sclerosis in monozygotic twins. Proc Natl Acad Sci U S A 2020 Sep 1; 117(35):21546-21556. PMID: 32817525 PMCID: PMC7474627 DOI: 10.1073/pnas.2003339117

Sina C Rosenkranz, Artem Shaposhnykov, Oliver Schnapauff, Lisa Epping, Vanessa Vieira, Karsten Heidermann, Benjamin Schattling, Volodymyr Tsvilovskyy, Wolfgang Liedtke, Sven G Meuth, Marc Freichel, Mathias Gelderblom, Manuel A Friese. TRPV4-Mediated Regulation of the Blood Brain Barrier Is Abolished During Inflammation. Front Cell Dev Biol. 2020 Aug 27; 8:849. eCollection 2020. PMID: 32974355 PMCID: PMC7481434 DOI: 10.3389/fcell.2020.00849

Katherine D LaClair, Qihui Zhou, Meike Michaelsen, Benedikt Wefers, Monika S Brill, Aleksandar Janjic, Birgit Rathkolb, Daniel Farny, Mikolaj Cygan, Martin Hrabe de Angelis, Wolfgang Wurst, Manuela Neumann, Wolfgang Enard, Thomas Misgeld, Thomas Arzberger, Dieter Edbauer. Congenic expression of poly-GA but not poly-PR in mice triggers selective neuron loss and interferon responses found in C9orf72 ALS. Acta Neuropathol. 2020 Aug; 140(2):121-142. Epub 2020 Jun 19. PMID: 32562018 PMCID: PMC7360660 DOI: 10.1007/s00401-020-02176-0 Free PMC article

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Georg Kislinger, Helmut Gnägi, Martin Kerschensteiner, Mikael Simons, Thomas Misgeld, Martina Schifferer. Multiscale ATUM-FIB Microscopy Enables Targeted Ultrastructural Analysis at Isotropic Resolution. iScience. 2020 Jul 24; 23(7):101290. Epub 2020 Jun 20. PMID: 32622266 PMCID: PMC7334410 DOI: 10.1016/j.isci.2020.101290

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Antje Schmidt-Pogoda, Nadine Bonberg, Mailin Hannah Marie Koecke, Jan-Kolja Strecker, Jürgen W ellmann, Nils-Martin Bruckmann, Carolin Beuker, Wolf-Rüdiger Schäbitz, Sven G Meuth, Heinz Wiendl, Heike Minnerup, Jens Minnerup.  Why Most Acute Stroke Studies Are Positive in Animals but Not in Patients: A Systematic Comparison of Preclinical, Early Phase, and Phase 3 Clinical Trials of Neuroprotective Agents. Ann Neurol. 2020 Jan; 87(1):40-51. Epub 2019 Nov 26. PMID: 31714631 DOI: 10.1002/ana.25643

Eckhard Schlemm, Robert Schulz, Marlene Bönstrup, Lutz Krawinkel, Jens Fiehler, Christian Gerloff, Götz Thomalla, Bastian Cheng. Structural brain networks and functional motor outcome after stroke-a prospective cohort study. Brain Commun 2020 Jan 10; 2(1): fcaa001. eCollection 2020. PMID: 32954275 PMCID: PMC7425342 DOI: 10.1093/braincomms/fcaa001

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Dirk M Hermann, Matthias Gunzer. Contribution of polymorphonuclear neutrophils in the blood periphery to ischemic brain injury. Neurol Neuroimmunol Neuroinflamm. 2019 May 15; 6(4):e570. doi: 10.1212/NXI.0000000000000570. eCollection 2019 Jul. PMID: 31355306 PMCID: PMC6624096 DOI: 10.1212/NXI.0000000000000570

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Dirk M Hermann, Matthias Gunzer. Polymorphonuclear Neutrophils Play a Decisive Role for Brain Injury and Neurological Recovery Poststroke. Stroke. 2019 Mar; 50(3):e40-e41. PMID: 30674233 DOI: 10.1161/STROKEAHA.118.021564

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